Start here. This is the direct spoken answer to practice first.
Why this question matters
OpenTelemetry defines portable instrumentation and telemetry semantics, while Application Insights provides an Azure monitoring backend and operating experience. A production design needs both a stable signal contract and a backend engineers can use during incidents.
OpenTelemetry is a vendor-neutral way to instrument traces, metrics, and logs and export them to different backends. Application Insights is an Azure monitoring backend and SDK experience with dashboards, dependency tracking, live metrics, and Azure integration. A .NET API can use OpenTelemetry instrumentation and send data to Application Insights or another observability backend.