Start here. This is the direct spoken answer to practice first.
Why this question matters
lock protects a short synchronous critical section, while SemaphoreSlim can coordinate asynchronous waits or permit a bounded number of concurrent operations. The choice depends on whether the design protects shared state or limits access to a resource.
I use lock to protect a small synchronous critical section around shared in-memory state. I use SemaphoreSlim when I need async-compatible waiting or when I want to allow a limited number of concurrent operations. I should not await inside a lock because that can lead to problems and the compiler prevents it. SemaphoreSlim has WaitAsync, so it fits async workflows better.